(4R)-3,11-dimethyl-4,8,9,12-tetrahydro-4,7-(metheno)furo[3,2-c]oxacycloundecin-6-one
Linderalactone
CAS: 728-61-0
Molecular Formula: C15H16O3
(4R)-3,11-dimethyl-4,8,9,12-tetrahydro-4,7-(metheno)furo[3,2-c]oxacycloundecin-6-one - Names and Identifiers
(4R)-3,11-dimethyl-4,8,9,12-tetrahydro-4,7-(metheno)furo[3,2-c]oxacycloundecin-6-one - Physico-chemical Properties
| Molecular Formula | C15H16O3 |
| Molar Mass | 244.29 |
| Density | 1.19±0.1 g/cm3(Predicted) |
| Melting Point | 136-138 °C |
| Boling Point | 437.9±45.0 °C(Predicted) |
| Specific Rotation(α) | -224.7°(c=0.52) |
| Flash Point | 218.619°C |
| Solubility | Soluble in chloroform, methanol |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White powder or crystal |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.572 |
| MDL | MFCD12031632 |
| Physical and Chemical Properties | Dried tubers derived from a plant of the family Lauraceae |
(4R)-3,11-dimethyl-4,8,9,12-tetrahydro-4,7-(metheno)furo[3,2-c]oxacycloundecin-6-one - Reference Information
| physical and chemical properties | density: 1.19g/cm3 Melting Point: 125-127 ℃ Boiling Point: 437.9°C at 760mmHg flash point: 218.6°C optical rotation:-224.7 °(c = 0.52) refractive index: 1.572 properties: white Crystal (ethyl acetate-n-hexane) molecular structure and commercial sample: see figure below |
| Overview | isobaric lactone is the main active substance of the genus Capsicum, which has the functions of warming the stomach and regulating qi, promoting Qi and relieving pain, and, the effect of warm kidney and cold. Modern pharmacological studies have shown that bird medicine has a wide range of pharmacological activities on the immune system, digestive system, cardiovascular system, central nervous system and antiviral. |
| extraction process | the extraction of isoaconitine lactone is mainly divided into the following parts: 1. Dissolution: take the appropriate amount of bird medicinal anhydrous ethanol heating with the same flow extraction, filtration, combined extract. 2. Extraction: the obtained extract was concentrated under reduced pressure and suspended in an appropriate amount of water, extracted with ether, and the ether extract was collected. After the ether was collected together, the concentrate was mixed with diatomite. 3. Through Column: silica gel column chromatography, gradient elution was carried out using dichloromethane-methanol system, the eluate was collected, concentrated, left standing, colorless needle crystals were precipitated, and the compound was obtained after recrystallization. |
| plant source | This medicine is mainly used to extract from the following plants: camphoridae, linderae root, zingiberis rubra root, the stem of nanrenshan new ginger root, villous new ginger root, etc. |
| characteristics | Modern pharmacological studies have shown that the bird medicine on the immune system, digestive system, cardiovascular system, central nervous system and anti-virus and other prescription and has a wide range of pharmacological activity. |
| identification method | HPLC method with the mobile phase of methanol-acetonitrile-water (35:25:40); the detection wavelength was 235nm, the column temperature was 40, and the flow rate was 1ml/min. |
| uses storage, etc. | uses: for content determination/identification/pharmacological experiments. Specification: 10mg/20Mg shelf life: 2 years storage conditions: 2-8°C refrigerated, sealed, protected from light |
| references | [1] National pharmacopoeia commission. Pharmacopoeia of the People's Republic of China (Part I)[M]. Beijing: Chemical Industry Press, 2010 [2] Yu Guixin, Tu Haitao, Xu Lushan, etc. Chemical constituents and pharmacological effects of radix linderae [J]. Chinese wild plant resources, 1999(18) [3] tu Junwei, Ruan Bing. Overview of studies on Phytoremediation and pharmacology of radix linderae [J]. Zhejiang Journal of Traditional Chinese Medicine, 2006(41) [4] Yan Lili. Studies on the chemical constituents of radix linderae [J]. China pharmaceuticals, 2013(22) [5] Wei Guoqing. Research progress on chemical constituents of linderae [J]. Journal of Chengdu University of Traditional Chinese Medicine, 2013(09) [6] zuomeiling. Investigation on the content of isomaconitine lactone in radix linderae [J]. Chinese Journal of Modern Medicine, 2013(23) [7] Shu Jia Ni. Determination of aconitine lactone, ethers lactone and isoaconitine lactone in aconitine by HPLC [J]. China Modern Drug Application, 2009(03) [8] Chen Yunfang, ed. Dictionary of Plant active ingredients Vol. Beijing: Chinese Medical Science and Technology Press. 2001 [9] Li W S,et al.Phytochemistry, 1993,32(6):1503 [10] Takeda K, et al.J Chem Soc,1964,4578 [11] Takeda K, et al.J Chem Soc,1970,(7):973 [12] Canadian patent: CA 1995,123:138731d |
| Use | for content determination/identification/pharmacological experiments and other pharmacological effects: anti-tumor effect |
Last Update：2024-04-10 22:29:15
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Product Name: Linderalactone Visit Supplier Webpage Request for quotationCAS: 728-61-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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